Sonapax tablets: instructions for use for children and adults

An antipsychotic that is used in adult and pediatric pediatrics for behavioral changes. The dosage and duration of treatment is selected by the doctor. You can not take Sonapax on your own, from drugstores the drug is available only by prescription. It can cause side effects from many organs and systems, as well as affect the pharmacological activity of other drugs.

Dosage form

Sonapax is available only in the form of tablets for oral administration. Packed in blisters for 20 pieces each. The package contains 2 or 3 blisters, also an insert with instructions for use. Externally, the tablets have a round shape, light pink or light yellow. On the market, the drug is provided in two doses of 10 mg and 25 mg. The basis of the drug is thioridazine, also auxiliary components.

Release form and composition

  • Coated tablets, 10 mg: biconvex, round, light pink, uniform in color (30 each in blister packs, 2 packs in a cardboard box),
  • Coated tablets, 25 mg: biconvex, round, light yellow, uniform in color (20 each in blister packs, 3 packs in a cardboard box),
  • Dragee, 10 mg: biconvex, round, uniform in color, without spots, light pink (30 pcs. In blisters, 2 blisters in a cardboard bundle),
  • Dragee, 25 mg: biconvex, round, uniform in color, spotless, light yellow (20 pcs. In blisters, 3 blisters in a cardboard bundle).

Composition 1 tablet 10 mg:

  • Active ingredient: thioridazine hydrochloride - 10 mg,
  • Auxiliary components: talc, stearic acid, gelatin, lactose monohydrate, colloidal silicon dioxide, corn starch,
  • Shell: talc, acacia gum, sucrose, crimson dye (Ponceau 4R).

Composition 1 tablet 25 mg:

  • Active ingredient: thioridazine hydrochloride - 25 mg,
  • Auxiliary components: talc, magnesium stearate, gelatin, sucrose, potato starch,
  • Shell: talc, acacia gum, sucrose, dye quinoline yellow.

Composition of 1 tablet of 10 mg:

  • Active ingredient: thioridazine hydrochloride - 10 mg,
  • Auxiliary components: gum arabic, sucrose, talc, stearic acid, gelatin, lactose, aerosil (colloidal silicon dioxide), corn starch, cochineal red dye.

Composition of 1 tablet of 25 mg:

  • Active ingredient: thioridazine hydrochloride - 25 mg,
  • Auxiliary components: gum arabic, talc, magnesium stearate, gelatin, sugar, potato starch, quinoline yellow dye.

Composition

The active substance of Sonapax, whose international name (INN) is thioridazine is an thioridazine hydrochloridewhich in one tablet contains 10 mg or 25 mg.

The auxiliary substances are: lactose monohydrate, talc, colloidal silicon dioxide, gelatin, corn starch, stearic acid.

The composition of the shell includes acacia gum, sucrose, talc, dye.

Description and composition

Sonapax is a drug of antipsychotic effect. It has antidepressant, antipsychotic and anti-autistic properties. The instructions for the drug contain information that this drug has a moderate a-adrenergic blocking and m-anticholinergic effect. Clinical trials have shown that Sonapax tablets blocks Hi-histamine and m-cholinergic receptors, eliminates anxiety, and eliminates nervousness and feelings of tension. The active component of the drug is thioridazine hydrochloride, which is widely used in psychiatry as a therapeutic or supportive agent.

One tablet contains 10 or 25 mg of active ingredient. The auxiliary components are talc, gelatin, stearic acid, colloidal silicon dioxide and other components.

Pharmacological group

Sonapax tablets are an antipsychotic used in psychiatry. The principle of action of the drug is its antipsychotic, antidepressant and tranquilizing effect. The main component of the drug - thioridazine has the ability to suppress adrenergic and dopamine impulse transmission in the structures of the brain. Taking the drug, its active component quickly penetrates the blood stream, penetrates the structures of the central nervous system.

Thioridazine, which is the basis of the drug, has a peripheral and central effect on the human nervous system, suppresses certain brain functions, thereby stabilizing the overall psychological state of a person. Sonapax, unlike other drugs from the group of antipsychotics, has a more pronounced peripheral effect on the structure of the brain. Tablets do not cause suppression of motor activity, do not have an antiemetic effect.

The drug is metabolized in the liver, partially excreted by the kidneys, intestines in an unchanged form.

Pharmacodynamics

Thioridazine belongs to the group of piperidine derivatives of phenothiazine and directly affects the central and peripheral nervous system. It has antiemetic, antipruritic, antidepressant, tranquilizing and antipsychotic effects.

The reason for the antipsychotic effect is the blockade of postsynaptic dopamine receptors located in the mesolimbic structures of the brain. The central antiemetic effect is caused by a blockade or inhibition of the functioning of dopamine D2 receptors located in the chemoreceptor trigger zone of the brain stem. The peripheral antiemetic effect is due to blockade of the vagus nerve in the digestive tract.

Thioridazine is also characterized by a-adrenergic blocking and m-anticholinergic action. Of all the antipsychotics, the substance is able to most effectively block Hi-histamine and m-cholinergic receptors. In small quantities, it produces an anxiolytic effect, reduces the feeling of anxiety and tension. When taking higher doses of Sonapax, its antipsychotic (antipsychotic) properties are manifested. Thioridazine also stimulates the production of prolactin by the pituitary gland and prolongs the QTc interval (severity depends on the dose), which can provoke severe ventricular arrhythmias with a possible fatal outcome, including “pirouette” tachycardia.

Indications for use

  • Schizophrenia (as a second-line drug in patients who are contraindicated in taking other drugs, or there is no therapeutic effect when taking other drugs),
  • Neuroses accompanied by depressive disorders, obsessive states, sleep disturbance, psychoemotional stress, psychomotor agitation, anxiety, fear,
  • Psychotic disorders accompanied by agitation and hyperactivity,
  • Severe behavioral disorders associated with the inability to prolong concentration of attention and aggressiveness,
  • Withdrawal syndrome (alcoholism, substance abuse),
  • Psychomotor agitation of various origins,
  • Behavioral disorders with increased psychomotor activity (in child psychiatry).

Additionally for dragees:

  • Skin diseases accompanied by severe and painful itching,
  • Tics, Huntington's disease,
  • Affective insanity,
  • Moderate and severe depression in adults.

Pharmacokinetics

The degree of absorption of thioridazine in the digestive tract is quite high. The maximum concentration of a substance in blood plasma is observed 1–4 hours after ingestion. Thioridazine binds to plasma proteins by approximately 90% and is metabolized in the liver, forming active metabolites of sulforidazine and mesoridazine. The elimination half-life makes 6–40 hours. Mesoridazine has greater pharmacological activity than the parent compound, has a longer half-life, binds to plasma proteins to a lesser extent, and the free fraction is higher than that of thioridazine.

The active component of Sonapax is excreted unchanged and in the form of metabolites through the kidneys (approximately 35%) and the intestines. Thioridazine also passes into breast milk.

For adults

Among the main indications for the appointment of Sonapax tablets are the following conditions:

  • manic psychosis
  • schizophrenia,
  • neuroses of various etiologies,
  • obsessive states
  • increased anxiety, panic attacks,
  • withdrawal syndrome
  • psychotic disorders
  • pronounced changes in behavior,
  • increased aggressiveness
  • depression in adults
  • itchy skin against a background of neurological diseases.

Contraindications

Absolute for tablets:

  • Severe inhibition of the central nervous system (CNS),
  • Long QT Syndrome,
  • A history of arrhythmias,
  • Liver failure,
  • Congenital low activity of CYP2D6 isoenzyme,
  • Lactase or sucrose / isomaltase deficiency, fructose or lactose intolerance, glucose-galactose malabsorption,
  • A history of blood diseases,
  • Coma of any origin,
  • Acute depression
  • Simultaneous therapy with drugs that extend the QT interval,
  • Children under 4 years old
  • Hypersensitivity to drug components and other phenothiazine derivatives.

Absolute for dragees:

  • Traumatic brain injuries
  • Progressive systemic diseases of the brain and spinal cord,
  • Severe cardiovascular failure,
  • Severe arterial hypotension,
  • Pheochromocytoma,
  • Porphyria
  • A history of blood diseases,
  • Coma of any origin,
  • Acute depression
  • Children under 4 years old
  • Pregnancy,
  • Breastfeeding period,
  • Hypersensitivity to drug components and other phenothiazine derivatives.

General relative (Sonapax should be used with caution, since there is a high probability of complications):

  • Alcoholism,
  • Pathological changes in the blood,
  • Mammary cancer,
  • Angle-closure glaucoma,
  • Clinical manifestations of prostate hyperplasia
  • Renal failure
  • Liver failure (for dragees),
  • Peptic ulcer of the stomach and duodenum (during exacerbation),
  • Diseases accompanied by an increased risk of thromboembolic complications,
  • Epilepsy,
  • Parkinson's disease,
  • Myxedema
  • Chronic diseases accompanied by respiratory failure (especially in children),
  • Reye's syndrome
  • Cachexia
  • Vomiting
  • Old age (for dragees).

During pregnancy, the use of all forms of Sonapax release is permissible only in cases where the expected therapeutic effect for the mother significantly exceeds the possible risk for the developing fetus. If it is necessary to use the drug by lactating women, during the treatment, breastfeeding should be interrupted.

Pharmachologic effect

It inhibits dopamine and adrenergic transmission at the level of the reticular formation of the trunk (mainly) and the cerebral cortex. It has antipsychotic (noted after 10-14 days of admission) and weak antidepressant effect. Blocks N1antihistamines and peripheral m-cholinergic receptors. It has the most pronounced antihistamine and anticholinergic effect among all drugs from the group of antipsychotics.

Dosage and administration

The dosage regimen is selected individually by the attending physician.

Tablets
The tablets are taken orally.

The drug is recommended to be taken in the following daily doses (tablets of 10/25 mg, respectively):

  • Schizophrenia: adults - the initial dose is 5-10 / 2-4 pcs. 3 times a day, with a possible gradual increase to the maximum daily allowance - 80/32 pcs. After the therapeutic effect is achieved, the dose can be reduced to the minimum maintenance. The total daily dose varies between 20-80 / 8-32 pcs., Divided into 2-4 doses. Children - the initial dose is determined on the basis of the calculation of 0.5 mg per 1 kg of body weight per day, divided into several doses. It is allowed to increase the dose to a maximum daily dose of 3 mg per 1 kg of body weight,
  • Psychomotor agitation, severe behavioral disorders associated with inability to prolong attention span or aggressiveness, psychotic disorders accompanied by agitation and hyperactivity: on an outpatient basis - 15-40 / 6-16 each. per day, in a hospital - 25-80 / 10-32 pcs. in a day. Usually, therapy is started with low doses - 2.5-7.5 / 1-3 pcs. per day, gradually increasing them to the optimal therapeutic. The duration of therapy is several weeks. Maintenance dose - 7.5-20 / 3-8 pcs. once a day at bedtime. In elderly patients, Sonapax is prescribed in a low dose - 3-10 pcs. (10 mg) per day,
  • Neuroses with mild cognitive and emotional impairment: 3-7.5 each. (10 mg) per day, with inefficiency, a gradual increase in dose to 5-20 / 2-8 pcs is possible. in a day,
  • Neuroses with somatic component: 1-7.5 pcs. (10 mg) per day. Treatment begins with a low dose, gradually increasing it to the optimal therapeutic,
  • Withdrawal syndrome: from 1-7.5 pcs. (10 mg each) up to 15-40 / 6-8 pcs. in a day,
  • Behavioral disorders with increased psychomotor activity (10 mg tablets): children 4-7 years old - 1-2 pcs. 2-3 times a day, 8-14 years - 2-3 pcs. 3 times a day, 15-18 years - 3-5 pcs. 3 times a day.

Jelly beans
Dragees are taken orally.

Sonapax is recommended to be taken in the following daily doses (10/25 mg tablets, respectively):

  • Adults: acute psychoses, mania, schizophrenia and agitated depression - on an outpatient basis, 15-40 / 6-8 pcs. per day, in a hospital setting of 25-80 / 10-32 pcs. in a day. Therapy begins with low doses, 2.5-7.5 / 1-3 pcs. per day, gradually increasing them to the optimal therapeutic. The duration of treatment is several weeks. Maintenance dose - 7.5-20 / 3-8 pcs. once a day at bedtime. For elderly patients, the drug is prescribed in low doses - 3-10 pcs. (10 mg) per day. Light mental and emotional disorders - 3-7.5 each. (10 mg) per day, moderate - 5-20 / 2-8 pcs. in a day. Treatment begins with low doses, gradually increasing them to the optimal therapeutic. Psychosomatic disorders - 1-7.5 pcs. (10 mg) per day. Severe itching - (20/4 pcs maximum),
  • Children (10 mg tablets): 4-7 years - 1-2 pcs. 2-3 times a day, 8-14 years, 2-3 pcs. 3 times a day, 15-18 years old - 3-5 pcs. 3 times a day.

The cancellation of Sonapax should be carried out gradually.

Indications Sonapaks ®

Schizophrenia, including paranoid, schizoaffective disorder, psychosis, including involutional, psychosomatic disorders, depressive states accompanied by a sense of fear, withdrawal symptoms in chronic alcoholism, itching (severe, painful) in skin diseases, behavioral disorders (increased psychomotor activity) in children.

Side effects

  • Hemopoietic system: pancytopenia, aplastic anemia, thrombocytopenia, eosinophilia, granulocytopenia, leukopenia, agranulocytosis,
  • Genitourinary system: priapism, dysuria, paradoxical ischuria, gynecomastia, hyperprolactinemia, dysmenorrhea, impaired ejaculation, decreased libido,
  • Endocrine system: weight gain, false positive pregnancy test,
  • Nervous system: confusion, agitation, insomnia, agitation, emotional disturbances, fainting, tardive dyskinesias, decreased seizure threshold, thermoregulation disorders, parkinsonism, extrapyramidal and dystonic disorders, in addition to tablets - malignant antipsychotic syndrome,
  • Digestive system: nausea, vomiting, dyspepsia, diarrhea, anorexia, increased appetite, cholestatic hepatitis, hyposalivation, hypertrophy of the papillae of the tongue, paralytic intestinal obstruction,
  • Cardiovascular system: tachycardia, lowering blood pressure, additionally for tablets - changing the electrocardiogram, including dose-dependent lengthening of the QT interval, tachycardia type pirouette,
  • Sense organs: photophobia, visual impairment,
  • Allergic reactions: skin allergic reactions, erythema, rash, nasal congestion, bronchospastic syndrome, angioedema, exfoliative dermatitis,
  • Dermatological reactions: with prolonged use in high doses - skin melanosis, additionally for tablets - photosensitivity.

Instructions for use of Sonapax: method and dosage

Sonapax tablets are taken orally.

The doctor determines the regimen of the drug individually, based on the severity of the condition.

Recommended dosage regimen for Sonapax:

  • schizophrenia: adults - from 50-100 mg (at the beginning of treatment) 3 times a day, with a gradual increase, if necessary, to the maximum dose - 800 mg / day, after reaching the effect, the dose is reduced to the lowest maintenance, the average daily dose is 200-800 mg in 2–4 doses, children - 0.5 mg / kg in several doses, in cases of need, an increase to the maximum is possible - 3 mg / kg,
  • psychomotor agitation of various origins, psychotic disorders that occur with agitation and hyperreactivity, severe behavioral disorders associated with inability to concentrate attention for a long time and aggressiveness: outpatient - 150-400 mg per day, stationary - 250-800 mg per day, therapy should be started with the use of low doses - 25–75 mg per day, gradually increasing to the optimal therapeutic, which is achieved within a week, the development of the antipsychotic effect is noted 10-14 days after the start and the treatment duration of the course is usually a few weeks, the maintenance dose - 75-200 mg per day before going to bed, once.

In elderly patients, the dose of Sonapax is usually reduced to 30-100 mg per day.

You need to cancel the drug gradually.

The scheme of use of Sonapax for other indications (daily dose):

  • neurosis with mild emotional / cognitive impairment: 30–75 mg, with inefficiency, the dose is gradually increased to 50-200 mg,
  • withdrawal syndrome: from 10–75 to 150–400 mg (depending on the severity of the condition),
  • neuroses with a somatic component: 10–75 mg, treatment should be started with low doses, gradually increasing them to optimal therapeutic ones,
  • behavioral disorders in children, accompanied by increased psychomotor activity: 4–7 years old - 2-3 times a day for 10–20 mg, 8–14 years old - 3 times a day for 20–30 mg, 15–18 years old - 3 times a 30-50 mg per day.

Instructions for use Sonapaksa (Method and dosage)

The tablets are taken orally, the dosage regimen for each patient is set individually.

Adults with psychoses usually prescribed on an outpatient basis, 150-400 mg per day, divided into 3-4 doses, in a hospital - 250-800 mg. It is necessary to start treatment with low doses (25-70 mg per day), gradually the dose size increases until the optimal effect is achieved (the antipsychotic effect is observed after the start of treatment after 10-14 days). Usually the course of treatment lasts several weeks. As a maintenance dose, 70-200 mg is prescribed once before bedtime. Older people are prescribed lower doses - 100-300 mg. It is necessary to cancel a drug gradually.

Therapeutic dose for lungs emotional and mental disorders per day is 50-200 mg.

At psychosomatic disorders 10-75 mg should be taken per day.

If it is necessary to suppress severe itching, the dose size is set individually, however, it should not be more than 200 mg.

Children aged 4-7 years per day should take 10-20 mg (in two or three doses), 8-14 years old - 20-30 mg (in three doses), 15-18 years old - 30-50 mg (in three reception).

Sonapax instructions forwithdrawal syndrome: patients are prescribed from 10 to 400 mg, depending on the degree of condition.

Dosage and Administration

Doses of the medicine, therapeutic treatment course can be prescribed by the doctor depending on the diagnosis, stage of the disease, the patient’s body characteristics. The drug is contraindicated for self-administration. Only a doctor can prescribe it after making a final diagnosis. The therapeutic course can last several weeks or months.

Drug interaction

Synergism of action is observed with the simultaneous use of Sonapax with atropine, ethanol, barbiturates, narcotic analgesics, general anesthetics.

The effect of thioridazine on drugs / substances with simultaneous use:

  • Hypoglycemic drugs: enhances their hepatotoxic effect,
  • Levodopa: reduces its antiparkinsonian effect,
  • Guanethidine: reduces its antihypertensive effect,
  • Other antihypertensive agents: enhances their action, which increases the risk of significant orthostatic hypotension,
  • Anticoagulants: weakens their effect,
  • Amphetamine: antagonizes its actions,
  • Lithium preparations: reduces their absorption from the gastrointestinal tract, increases the rate of excretion of lithium ions by the kidneys, increases the severity of extrapyramidal disorders, can mask early signs of lithium intoxication (nausea and vomiting),
  • Beta-blockers: enhances their antihypertensive effect,
  • Means that reduce appetite: reduces their effect (the exception is fenfluramine),
  • Apomorphine: reduces the effectiveness of its emetic effect, enhances the inhibitory effect on the central nervous system,
  • Prolactin: increases its concentration in plasma,
  • Bromocriptine: inhibits its action,
  • Tricyclic antidepressants, maprotiline, monoamine oxidase inhibitors, histamine H blockers1-receptors: can lengthen and enhance their sedative and m-anticholinergic effects.

With the combined use of thioridazine with drugs that extend the QT interval and inhibitors of the isoenzyme CYP2D6, the development of arrhythmias, including tachycardia such as pirouette, with pindolol, propranolol, fluvoxamine - an increased risk of arrhythmias, with epinephrine - a sudden and pronounced decrease in arterial pressure, with lowering blood pressure, with quinidine, procainamide, pimozide, erythromycin, disopyramide, cisapride, astemizole, probucol - an additional lengthening of the QT interval, which lichivaet risk of ventricular tachycardia with antithyroid drugs - increase the risk of agranulocytosis, a thiazide diuretic - strengthening of hyponatremia.

Cimetidine and anticonvulsants with simultaneous use with thioridazine can weaken its effect, quinidine - potentiate the cardiodepressive effect, sympathomimetics - enhance arrhythmogenic effect,

Overdose

An overdose of the drug has the following symptoms:

  • ECG change ventricular fibrillation, arrhythmias, ventricular tachycardia, lengthening of intervals PR and QT, bradycardiasinus tachycardia, pressure reduction, inhibition of myocardial function,
  • sedative effect hypothermia, comaconfusion, extrapyramidal disorders, hyperthermia, agitation, areflexia,
  • urinary retention mydriasisdry skin, nasal congestion, miosisblurred vision
  • apnea, respiratory depression, pulmonary edema,
  • constipation, decreased motility of the gastrointestinal tract, intestinal obstruction,
  • uremia, oliguria.

The manifestation of toxicity occurs when the concentration of thioridazine is more than 10 mg / l in plasma, death occurs at a concentration of 20-80 mg / l.

For treatment, it is necessary to establish pulmonary ventilation and adequate oxygenation. It is necessary to conduct an ECG. The essence of therapy in the correction of electrolyte disturbances, you must enter lidocaine, being careful, as there is a risk of seizures, isoproterenol, phenytoin. It should be applied quinidine, procainamideand disopyramids, since they can affect the increase in the QT interval.

To suppress acute extrapyramidal disorders, you should use trihexyphenidylor diphenhydramine.

Interaction

Reception of Sonapaks can strengthen action antihypertensive, analgesic, narcotic and sleeping pillsmeans, as well as alcohol, increase the anticholinergic effect amitriptyline.

Sonapax reduces action amphetamine, levodopa.

Drug combination with ephedrinemay cause hypotension. Anti-steroid drugs in combination with this drug increase the risk of agranulocytosis.

Lengthening the QT interval may be caused by taking probucola, cisapride, astemizole, pimozide, erythromycin, quinidineand disopyramidthat can lead to development ventricular tachycardia.

Special instructions

During the use of Sonapax, the morphological composition of the blood should be controlled.

Ethanol should not be used during thioridazine therapy.

According to the instructions, Sonapax weakens motor coordination and reduces the speed of psychomotor reactions, especially at the beginning of therapy, therefore it is recommended to refuse to drive vehicles and maintain moving mechanisms during the period of use of the drug.

For pregnant and lactating

Clinical trials regarding the administration of the drug for pregnant women have not been conducted, so this drug can not be prescribed to pregnant and lactating women.

Contraindications

Before using the drug, it is important to familiarize yourself with contraindications, including:

  • arrhythmia,
  • blood diseases
  • children under 4 years old,
  • depressive state
  • cachexia
  • angle-closure glaucoma,
  • epilepsy.

Dosage and Administration

Doses of the medicine, therapeutic treatment course can be prescribed by the doctor depending on the diagnosis, stage of the disease, the patient’s body characteristics. The drug is contraindicated for self-administration. Only a doctor can prescribe it after making a final diagnosis. The therapeutic course can last several weeks or months.

For adults

For mild intellectual and emotional disorders, an average dose of 50 to 200 mg per day is prescribed. Initial doses of the drug should be minimal.

With severe psychosis, neurosis, 25 to 75 mg per day is prescribed. After a while, the dose may increase to 800 mg per day. With an improvement in the general condition of the patient, the dose is gradually reduced, amounting to not more than 200 mg per day.

In psychosomatic disorders, the average daily dose is 10-75 mg per day.

For children

In pediatrics, the drug is used in minimal therapeutic doses. At the age of 4 to 7 years, the dose of the drug cannot exceed 10 mg per day. From 7 to 12 years old - 20-30 mg per day. It is prohibited to use the drug without first consulting a doctor.

For pregnant and lactating

During pregnancy and lactation, the drug is not used.

Schizophrenia

The initial dose of sonapax for the treatment of schizophrenia in adults is 50-100 mg 3 times a day. Further (with insufficiently pronounced effect) the dose can be increased to 200 - 250 mg 3-4 times a day (not exceeding a daily dose of 800 mg).

The treatment of schizophrenia in children begins with a daily dose of 0.5 mg of the drug per kilogram of the child’s weight (the dose should be divided into 2 to 4 doses) If necessary, the daily dose can be increased to 3 mg per kilogram.

Dosage and administration

Inside. The dosage regimen is individual (depending on the indications and therapeutic response).

In psychoses: for adults, usually 150-400 mg / day in 3-4 doses on an outpatient basis, in a hospital - 250-800 mg / day. Treatment usually begins with low doses, 25–75 mg / day, gradually increasing them to the optimal therapeutic dose, which is achieved within 7 days (antipsychotic effect is noted after 10-14 days). The course of treatment is several weeks. The maintenance daily dose is 75-200 mg once before bedtime. In older people, low doses of 30-100 mg / day are usually used. The drug should be discontinued gradually.

For mild mental and emotional disorders: therapeutic dose - 50-200 mg / day. Treatment should begin with low doses, gradually increasing them to the optimal therapeutic dose.

With psychosomatic disorders - 10–75 mg / day.

To suppress severe itching: the dose of the drug is set individually, and it should not exceed 200 mg.

Children from 4 to 7 years old - 10-20 mg / day in 2-3 doses per day, from 8 to 14 years old - 20-30 mg / day in 3 divided doses per day, from 15 to 18 years old - 30-50 mg / day in 2-3 doses per day.

Hyperactivity and Nerve Tics

Hyperactivity is a pathological condition in which a person has excessively expressed mobility, mild or moderate excitement. Such a patient can be in constant motion, perform various aimless actions (for example, getting up from a chair several times and sitting on it again) etc. These disorders are caused by a dysfunction of the central nervous system, neurosises, psychoses, psychoemotional shocks, and so on.

Nerve tic is one of the varieties of hyperactivity in which the patient regularly performs certain violent movements (for example, jerking with an eye, arm or leg, winking, grimacing, and so on) The patient controls these movements, but psychologically cannot prevent them. The development of nerve tics is associated with increased sensitivity of certain sections of the central nervous system to dopamine. By blocking dopamine receptors, sonapax can reduce the severity of nerve tics.

For the treatment of nerve tics, the drug is prescribed at a dose of 25 - 75 mg 1 - 2 times a day, increasing it by 25 - 50 mg every day. The maximum daily dose should not exceed 400 mg. Positive effects (decreased severity of nerve tics) are observed no earlier than after 10-14 days, and the course of treatment can reach several months.

Precautionary measures

It is used with caution in case of prostatic hypertrophy with difficulty urinating, angle-closure glaucoma, myasthenia gravis, Parkinson’s disease, diseases of the cardiovascular system, peptic ulcer, renal and / or liver failure. With prolonged treatment, it is necessary to control the blood picture. It should not be used while drivers of vehicles and people whose profession is associated with increased concentration of attention. During treatment, the use of alcohol is excluded. Cancel the drug should be gradual.

Reviews about Sonapaks

According to reviews, Sonapax is a mild antipsychotic with a weak effect, which is well tolerated and rarely provokes adverse reactions. However, some patients claim that prolonged use can lead to impotence.

Doctors consider the drug effective, but some of them note that there are more modern analogues, and besides, sometimes Sonapax has an adverse effect on the work of the heart.

Since Sonapax is harmless for children, and they tolerate it well, the drug is often prescribed for hyperactive children with attention deficit. Feedback on its use in this case varies significantly. Some parents say that the drug helped, others complain of increased activity or, conversely, the child’s unusual inhibition after taking it.

Analogs

If there is a need to replace the drug, the doctor may prescribe drugs similar in composition or therapeutic effect:

  • Melleril is an antipsychotic, which can relieve tension and anxiety, and can be used in the treatment of depressive disorders.
  • Thioridazine is a structural analogue of a drug that has antipsychotic, antidepressant, tranquilizing, antiemetic and antipruritic properties.
  • Thioril is a drug from the group of alpha-blockers with m-anticholinergic action. Taking the drug can increase the concentration of attention, improve memory, reduce the risk of vascular pathologies.

Taking any analogue without first consulting a doctor can provoke symptoms of side effects, worsen the general condition of patients. Only the attending physician can prescribe analogues, individually selecting the dose of the drug.

The cost of Sonapaks is an average of 351 rubles. Prices range from 233 to 520 rubles.

Dementia

This disease is characteristic of the elderly and senile. Its essence lies in the fact that a person loses almost all the skills acquired during his life, and only primitive reflexes and behavioral reactions are preserved in him. At the same time, the patient may experience periods of psychomotor agitation, during which he becomes restless or even aggressive, may scream (usually unrelated words or inarticulate sounds), swing their arms and / or legs and so on, while posing a danger to both themselves and others.

Sonapax can be used to eliminate these symptoms, but it is advisable to combine it with other sedatives. The initial dose of sonapax should be minimal (10 mg 1 - 2 times a day), since its increase too quickly can lead to excessive inhibition of the central nervous system and to the development of complications. Further (in the absence of the necessary therapeutic effect) the dose of the drug can be increased by 25 mg every 2 to 3 days, without exceeding the maximum daily dose of 400 mg.

Prescribing Sonapax to Children with Autism

Autism is a congenital pathology that manifests itself from the first years of a child’s life. Its essence lies in the fact that due to the underdevelopment of certain parts of the brain, the child interacts poorly with the outside world and with people, remains closed and uncommunicative, while the mental processes and learning abilities of him are partially or fully preserved.

In most cases, children with autism are calm and do not pose a danger to others. The treatment of such patients is carried out using psychotherapy and other methods of psychological impact. At the same time, drugs can sometimes be prescribed that improve the metabolism in the brain and stimulate its development.

It is extremely rare for patients with autism to have signs of mental illness. In this case, sick children can be excited or even aggressive, harm themselves or others. Initially, sedatives and methods of psychological correction are recommended for the treatment of these disorders, but only with their ineffectiveness use antipsychotics (particularly sonapax) This is due to the fact that when prescribing antipsychotics, severe disorders of the nervous system can develop, however, children with autism will not be able to adequately report this to the attending physician, since they have poor contact with others.

The initial dose of the drug for the treatment of mental disorders in autism should not exceed 10 mg per day. If treatment is ineffective, the daily dose may be increased depending on the age and body weight of the child.

How long and how long does sonapax last?

After a single dose of the drug, its maximum effect develops after 2 to 4 hours. Half-life (that is, the time during which half the dose introduced into the body will be removed from it) is from 6 hours to 2 days. During all this time, the drug can have its inhibitory effect on the central nervous system (CNS).

At the same time, it is worth noting that for the development of the most pronounced clinical effect, the drug should be taken for a longer time (several days or even weeks), gradually increasing the daily dose. In this case, the concentration of the active substance in the patient’s blood will also gradually increase, as a result of which its inhibitory effect at the central nervous system level will increase.

How long can I take sonapax?

On average, the course of taking Sonapax lasts from several weeks to several months. At the same time, it is worth noting that the duration of treatment is determined by the doctor individually in each case and depends on a number of factors.

The duration of taking sonapax is determined by:

  • Nature of the disease - with congenital and chronic mental disorders, the drug can be prescribed for a longer time than with temporary mental disorders.
  • Severity of disease - the more pronounced the symptoms of the disease, the greater the dose of sonapax, and the longer it will be prescribed.
  • General condition of the patient - if there are contraindications from various organs and systems, the drug can be prescribed only in case of emergency and only in short courses.
  • The effectiveness of the treatment - if the appointment of Sonapax does not give the desired result for a certain time, it is not advisable to continue further treatment with this drug.
  • Adverse reactions - with their development, the dosage and duration of treatment with sonapax can be reduced.

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